We have a new opportunity for Senior Research Fellow with our client based in Dublin.
Location: Dublin, Ireland
Contract: 30-Month Fixed Term
Salary & Benefits: Competitive package including pension, private health insurance, income protection, 25 days annual leave (plus additional company days), flexible working, and strong career development support.
Role Overview
We are seeking a Senior Research Fellow to join a multidisciplinary consortium focused on advancing a dual-cell therapy for neonatal hypoxia-associated brain injury. This is a high-impact translational research role, supporting the transition from preclinical development toward First-In-Human, Phase 1 clinical trials.
The role offers the opportunity to lead analytical development, explore critical quality attributes (CQAs), and develop potency matrices while driving innovative research in neurovascular injury models.
Key Responsibilities:
- Design, optimize, and validate in vitro hypoxia and neurovascular models relevant to neonatal brain injury.
- Conduct proteomic and transcriptomic analyses (RNA-seq) to study mechanisms of action for MSC and ECFC co-therapy.
- Integrate multi-omics data to identify therapeutic pathways and biomarkers.
- Define and monitor CQAs (identity, purity, viability, immunophenotype) and develop potency assays.
- Develop release assays ensuring product consistency and regulatory compliance.
- Lead a multidisciplinary team, managing project milestones, deliverables, and data quality.
- Mentor junior researchers and PhD students.
- Prepare manuscripts, grant reports, and contribute to regulatory submissions.
- Present findings at scientific conferences, consortium meetings, and stakeholder briefings.
Essential Criteria
- PhD in Neuroscience, Cell Therapy, Regenerative Medicine, Biotechnology, or a related field.
- 4+ years post-PhD experience in relevant research areas.
- Proven leadership with a strong publication record, international conference presentations, and supervision of junior staff/PhD students.
- Expertise in cell biology (MSCs, ECFCs) and neuronal/neurovascular models.
- Hands-on experience with omics technologies (proteomics, transcriptomics) and data analysis.
- Experience in defining CQAs, potency assays, and ATMP release criteria.
- Familiarity with regulatory frameworks for ATMPs and translational research toward clinical trials.
- Strong project management, analytical, and communication skills.
For further details on this opportunity, please reach out to Gillian Nicholson to gillian.nicholson@collinsmcnicholas.ie